Séminaires

Le séminaire hebdomadaire du laboratoire PMMH a lieu tous les vendredis à 11h, au premier étage Barre Cassan, campus Jussieu (plan).

Contact :
Stéphane Perrard
Etienne Reyssat
Virgile Thiévenaz
responsables-seminaires (arobase) pmmh.espci.fr

PMMH
BARRE CASSAN
BAT A 1ER ETAGE CASE 18
7 QUAI SAINT BERNARD
75005 PARIS
France

Tel : (33) 1 40 79 45 22


Guillaume Romet-Lemonne (LEBS, Gif-sur-Yvette)

Vendredi 13 janvier 2012 de 11h00 à 12h00 - Bureau d'Etudes

Studying the dynamics of individual actin filaments using microfluidics

Actin filaments are an essential part of the cytoskeleton, and drive various cell processes, during which they elongate, disassemble and form different architectures. Actin filament assembly is itself a complex mechanism, in which ATP-bound actin monomers are incorporated into filaments, where they hydrolyze their ATP. As a result, the filament is composed of actin monomers in different nucleotide states. This has many consequences for the filament structure, dynamics, mechanical properties, and for its interaction with regulatory proteins.
Using microfluidic, we have developed experimental configurations where individual actin filaments are manipulated in vitro, in order to observe their assembly and disassembly, as well as their interaction with regulatory proteins. This allows us to quantitatively study the dynamics of individual events, while controlling the filament's biochemical environment. I will show how this has enabled us to reveal molecular details of the filament composition and dynamics, and to solve a recent controversy regarding the stability of aging filaments.

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Séminaires  (4)

  • Séminaire PMMH - Francesca Borghi Università degli Studi di Milano
    Vendredi 20 juin de 11h00 à 12h00 - Salle réunion PMMH 1
    REPROGRAMMABLE HARDWARE FOR DATA PROCESSING AT THE EDGE : A NEW COMPUTING PARADIGM BASED ON NEUROMORPHIC SYSTEMS
    The brain's ability to perform efficient and fault-tolerant data processing is strongly related with its peculiar interconnected adaptive architecture, based on redundant neural circuits interacting at different scales. By emulating the brain's processing and learning mechanisms, computing technologies strive to (…)
  • Séminaire PMMH - Francesca Borghi Università degli Studi di Milano
    Vendredi 20 juin de 11h00 à 12h00 - Salle réunion PMMH 1
    REPROGRAMMABLE HARDWARE FOR DATA PROCESSING AT THE EDGE : A NEW COMPUTING PARADIGM BASED ON NEUROMORPHIC SYSTEMS
    The brain's ability to perform efficient and fault-tolerant data processing is strongly related with its peculiar interconnected adaptive architecture, based on redundant neural circuits interacting at different scales. By emulating the brain's processing and learning mechanisms, computing technologies strive to (…)
  • Séminaire PMMH - Salvatore Federico (University of Calgary, Canada)
    Vendredi 4 juillet de 11h00 à 12h00 - Salle réunion PMMH 1
    Continuum Mechanics of Hydrated Fibre-Reinforced Soft Tissues
    Biological tissues can be represented as bi-phasic continua, with a porous solid phase saturated by an interstitial fluid and reinforced by collagen fibers. This lecture will give an overview of the modelling techniques for fibre-reinforced porous composite materials with statistical orientation of the fibers. Both (…)
  • Séminaire PMMH - Salvatore Federico (University of Calgary, Canada)
    Vendredi 4 juillet de 11h00 à 12h00 - Salle réunion PMMH 1
    Continuum Mechanics of Hydrated Fibre-Reinforced Soft Tissues
    Biological tissues can be represented as bi-phasic continua, with a porous solid phase saturated by an interstitial fluid and reinforced by collagen fibers. This lecture will give an overview of the modelling techniques for fibre-reinforced porous composite materials with statistical orientation of the fibers. Both (…)

Instructions générales pour les conférenciers

Le public du séminaire est très hétérogène (rien qu’au PMMH nous travaillons sur des thématiques très diverses, mécanique des fluides, des milieux granulaires, des solides, physique statistique, physique du mouillage, micro-fluidique, biophysique,...) l’objectif est donc de ne pas faire un séminaire trop spécialiste : au moins la première moitié du séminaire à un niveau accessible pour celui qui ne connaît rien sur le sujet.

Le séminaire a lieu à 11h. rendez-vous 15 minutes avant pour installer et tester la projection.

Le séminaire dure environ 45 minutes pour laisser un peu de temps pour discuter à la fin.

Lien vers séminaires café (internes, tous les jeudis)


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Informations Pratiques

Laboratoire : 01 40 79 45 22
Directeur : Ramiro GODOY DIANA
Codirecteur : Laurent DUCHEMIN
Administratrice : Frédérique AUGER (01 40 79 45 22)
Gestionnaire : Claudette BAREZ (01 40 79 58 53)
Courriel : dir (arobase) pmmh.espci.fr