ESPCI web site
Séminaire Café (Interne)
Il s’agit d’un exposé assez court (20 min) et assez informel.
Prière aux conférencier·ère·s de ne jamais dépasser 30 min et de vérifier la compatibilité avec le projecteur avant le séminaire.
Les séminaires ont lieu les jeudis après la réunion du laboratoire qui débute à 13h30 dans la bibliothèque du labo sur le campus Jussieu, Barre Cassan, Bât A, 1er étage.
Pour suggérer un titre et envoyer un abstract, contacter 
et 
.
Coffee seminars are supposed to be short and informal presentations (20 min).
Please never last longer than 30 min and check the compatibility of the projector with your computer before the seminar.
Location : Campus Jussieu, Barre Cassan, Bât A, 1er étage
7 quai Saint Bernard
75005 Paris
To suggest a title or send an abstract, please contact and
| 12 février | Blandine Pommier - CNRS Innovation Comment financer mon innovation ? |
| 19 février | Melissa Dewulf - EnLife, PSL Grand Programme PSL - Engineering Life (short presentation) Matteo Brizioli - Universita’ degli Studi di Milano Surface of biomolecular condensates : a distorted mirror reflecting their material properties Over the past decade, increasing evidence has emerged for the existence and importance of membranelles compartments in cells1. These dynamic structures form via condensation of proteins and RNA, a process known as liquid-liquid phase separation2. Exhibiting fluid-like properties, condensates can rapidly assemble, coalesce and dissolve to regulate diverse biological functions, such as molecular sequestration, gene expression and enzymatic activity3. Their physiological role is inherently related to material properties like viscosity, elasticity and surface tension. Alterations in these properties, through processes like aberrant gelation or aggregation, may be associated with neurodegenerative diseases, where proteins abnormally cluster4. Thus, devising new approaches to reliably characterize condensates material properties is pivotal. In this work, we employ Differential Dynamic Microscopy (DDM)5 to probe in vitro models of biomolecular condensates. This non-invasive technique analyzes microscope images to extract dynamical information akin to light-scattering. By applying DDM to single condensates, we demonstrate its ability to characterize the relaxation dynamics of thermally driven surface fluctuations at the interface between the condensed and the dilute phases, enabling the estimation of key parameters such as surface tension and viscosity. Our approach opens new possibilities for assessing and linking condensate material properties to biological function and dysfunction. References : [1] C.P. Brangwynne, C.R. Eckmann, D.S. Courson, A. Rybarska, C. Hoege, J. Gharakhani, F. Jülicher, and A. A. Hyman. Science, 2009, 324.5935 : 1729-1732. [2] S. Alberti, A. Gladfelter, and T. Mittag. Cell, 2019, 176.3 : 419-434. [3] D. Bracha, M.T. Walls, and C. P. Brangwynne. Nature biotechnology, 2019, 37.12 : 1435-1445. [4] S. Alberti, Simon, and S- Carra. Journal of molecular biology, 2018, 430.23 : 4711-4729. [5] R. Cerbino, V. Trappe. Physical review letters, 2008, 100.18 : 188102. |
| 26 février | Présentations des 2ème année - PMMH Baptiste Vauléon & Petr Soyfer |
