ESPCI web site
PMMH’s weekly seminar is held every Friday at 11 am (map)
Stéphane Perrard
Etienne Reyssat
Virgile Thiévenaz
PMMH
BARRE CASSAN
BAT A 1ER ETAGE CASE 18
7 QUAI SAINT BERNARD
75005 PARIS
France
Tel : (33) 1 40 79 45 22
Séminaire PMMH - Emmanuèle Helfer (CINAM, Marseille)
Biomimicking red blood cell filtration by the spleen
Blood circulation in our vascular system is a physical tour de force. To distribute oxygen throughout the body, Red blood cells (RBCs) continuously travel through the microcirculation, through thin capillaries that are smaller than their size, and are thus highly deformable. Their deformability is periodically monitored by the spleen : when too rigid and unable to pass through the inter-endothelial splenic slits (IESs) of submicron width, RBCs are trapped in the spleen and destroyed. Today, due to lack of suitable in vitro devices and validated computational approaches, the mechanisms of RBC filtration by the IESs are still poorly understood. Here, by combining biomimicking experimental measurements and quantitative numerical simulations we elucidate the mechanisms of passage of RBCs through IESs.
We developed a microfluidic device containing high aspect ratio slits (2-µm long, 5-µm high, < 1-µm wide), reproducing the physiological dimensions of the IESs [1] and validated a numerical model of RBCs passing through splenic-like slits [2]. We couple these approaches to understand retention rates, transit times and cell deformations of RBCs squeezing in splenic-like slits as a function of external parameters (slit dimensions, pressure drop, temperature).
[1] P. Gambhire et al. Small 13, 1700967 (2017)
[2] H. Lu and Z. Peng. Physics of Fluids 31, 031902 (2019)
The audience is composed of people with rather heterogeneous backgrounds including specialists in solids, fluids, granular flows, statistical physics... so the idea is to keep your talk understandable by people not necessarily working in your field... The seminar time slot runs from 11am to noon so the best is to make the talk last around 45 minutes to leave some time for discussion.
- Séminaires ESPCI-ENS de biophysique
- Séminaires du Département de Physique de l’ENS
- Séminaires du Laboratoire d’Hydrodynamique de l’X
- Séminaire de Mécanique d’Orsay (page web FAST)
- Séminaire de Mécanique d’Orsay (page web LIMSI)
- Séminaire de Mécanique des Fluides de l’Institut Jean le Rond d’Alembert
- Séminaires du laboratoire MSC, Paris VII
- Séminaires Gulliver
Link to cofee seminar (internal, every Thursday)
