ESPCI web site
PMMH’s weekly seminar is held every Friday at 11 am (map)
Stéphane Perrard
Etienne Reyssat
Virgile Thiévenaz
PMMH
BARRE CASSAN
BAT A 1ER ETAGE CASE 18
7 QUAI SAINT BERNARD
75005 PARIS
France
Tel : (33) 1 40 79 45 22
Séminaire PMMH - Pascal Hersen (Institut Curie)
Playing with cellular functions and genetic circuits in real time
Gene expression plays a central role in the orchestration of cellular processes. In the past years, we have developed several methods to dynamically perturb, manipulate and control genetic circuit and cellular functions in yeast and bacteria using microfluidics and optogenetics. We developed an experimental method to achieve real time closed loop control of gene expression. This creates a dynamic interaction between cells and a computer, making it possible to precisely control the level of expression of a gene for both time-constant and time-varying target profiles, at the population level, and at the single-cell level. I will discuss this method, called cybergenetics, as well as recent examples showing how spatiotemporal perturbations, obtained thanks to optogenetics, can inform us quantitatively on the dynamics of cellular processes.
The audience is composed of people with rather heterogeneous backgrounds including specialists in solids, fluids, granular flows, statistical physics... so the idea is to keep your talk understandable by people not necessarily working in your field... The seminar time slot runs from 11am to noon so the best is to make the talk last around 45 minutes to leave some time for discussion.
- Séminaires ESPCI-ENS de biophysique
- Séminaires du Département de Physique de l’ENS
- Séminaires du Laboratoire d’Hydrodynamique de l’X
- Séminaire de Mécanique d’Orsay (page web FAST)
- Séminaire de Mécanique d’Orsay (page web LIMSI)
- Séminaire de Mécanique des Fluides de l’Institut Jean le Rond d’Alembert
- Séminaires du laboratoire MSC, Paris VII
- Séminaires Gulliver
Link to cofee seminar (internal, every Thursday)
