ESPCI web site
Séminaire café 2026
| 8 janvier | Présentations des 2ème année - PMMH Gareth Kergourlay & Thibault Papin |
| 15 janvier | Présentations des 2ème année - PMMH Giovanni Russo & Zheming Zhang |
| 22 janvier | Hector Urra - IUSTI Detachment of a highly concentrated suspension drop |
| 29 janvier | José Da Costa et Alexandra Vieira - SU Présentation de SUMMIT, unité de service de Sorbonne Université dédiée à l’ingénierie de la recherche et au développement de collaborations scientifiques et industrielles. |
| 5 février | Léa Cailly - CEMEF, Mines Paris PSL Stretching, contact line receding and breakup dynamics of capillary bridges between a hydrophobic surface and a bath |
| 12 février | Blandine Pommier - CNRS Innovation Comment financer mon innovation ? |
| 19 février | Melissa Dewulf - EnLife, PSL Grand Programme PSL - Engineering Life (short presentation) Matteo Brizioli - Universita’ degli Studi di Milano Surface of biomolecular condensates : a distorted mirror reflecting their material properties Over the past decade, increasing evidence has emerged for the existence and importance of membranelles compartments in cells1. These dynamic structures form via condensation of proteins and RNA, a process known as liquid-liquid phase separation2. Exhibiting fluid-like properties, condensates can rapidly assemble, coalesce and dissolve to regulate diverse biological functions, such as molecular sequestration, gene expression and enzymatic activity3. Their physiological role is inherently related to material properties like viscosity, elasticity and surface tension. Alterations in these properties, through processes like aberrant gelation or aggregation, may be associated with neurodegenerative diseases, where proteins abnormally cluster4. Thus, devising new approaches to reliably characterize condensates material properties is pivotal. In this work, we employ Differential Dynamic Microscopy (DDM)5 to probe in vitro models of biomolecular condensates. This non-invasive technique analyzes microscope images to extract dynamical information akin to light-scattering. By applying DDM to single condensates, we demonstrate its ability to characterize the relaxation dynamics of thermally driven surface fluctuations at the interface between the condensed and the dilute phases, enabling the estimation of key parameters such as surface tension and viscosity. Our approach opens new possibilities for assessing and linking condensate material properties to biological function and dysfunction. References : [1] C.P. Brangwynne, C.R. Eckmann, D.S. Courson, A. Rybarska, C. Hoege, J. Gharakhani, F. Jülicher, and A. A. Hyman. Science, 2009, 324.5935 : 1729-1732. [2] S. Alberti, A. Gladfelter, and T. Mittag. Cell, 2019, 176.3 : 419-434. [3] D. Bracha, M.T. Walls, and C. P. Brangwynne. Nature biotechnology, 2019, 37.12 : 1435-1445. [4] S. Alberti, Simon, and S- Carra. Journal of molecular biology, 2018, 430.23 : 4711-4729. [5] R. Cerbino, V. Trappe. Physical review letters, 2008, 100.18 : 188102. |
| 26 février | Présentations des 2ème année - PMMH Baptiste Vauléon & Petr Soyfer |
